Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Amines, salicylates and the blood-brain barrier

with one comment

The blood-brain barrier is a protective membrane that surrounds the brain. It is designed to keep various nasty substances out of the brain to prevent them from wreaking havoc. It doesn’t always manage to do its job though.

Salicylates cross the blood-brain barrier and are found in fetal tissue and breast milk. Salicylate toxicity occurs in the central nervous system. I wonder how much of this toxicity occurs inside the brain? Salicylate toxicity results in respiratory alkalosis and metabolic acidosis. The acidosis then prevents salicylates from being excreted by the kidneys.

Behaviour and emotional/psychological sensitivity to amines implies there could be some sort of permeability of the blood-brain barrier.

There are many ways to damage or increase the permeability of the blood-brain barrier:

  • Metabolic acidosis
  • Salicylates, via metabolic acidosis
  • Electro-convulsive shocks
  • Insulin induced hypoglycaemia
  • Salicylates, via insulin induced hypoglycaemia
  • Meningitis and other infections
  • Inflammation
  • Lack of essential fatty acids and saturated fat in the diet
  • Consumption of hydrogenated (trans-) fats and polyunsaturated (vegetable) oils
  • Mercury (fillings, vaccines, fish content of diet)
  • Dysfunctional methylation of cells due to lack of B12, folate, B6 and magnesium
  • Dietary lectins (grains, potatoes, legumes, soy, some vegetables)
  • Pathogenic lectins (strep, h. pylori, and a number of other bacteria and viruses)

The blood-brain barrier is not fully developed in infants, so they are particularly vulnerable. There are eight identified risk factors for childhood behaviour disorders: “food and additive allergies, heavy metal toxicity and other environmental toxins, low-protein/high-carbohydrate diets, mineral imbalances, essential fatty acid and phospholipid deficiencies, amino acid deficiencies, thyroid disorders, and B-vitamin deficiencies.”

I wonder what the cause and effect relationship is?


Written by alienrobotgirl

7 March, 2006 at 2:48 pm

One Response

Subscribe to comments with RSS.

  1. My 18 month olad daughter has “pseudo-allergies”, true allergies, intolerances and is hypersensitive to amines, salicylates and some additives. She lives on rice, green beans and very fresh, lightly cooked lamb. If I add the SCD as has been suggested due to bacterial overgrowth..that will cut out rice and then her already scant diet will be non existant what can she eat? Has anyone overcome these things with other methods?


    7 April, 2007 at 6:12 am

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: