Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Salicylates and mast cells

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I wish I knew what the abstract for this study concluded. “Interaction of carbohydrates and anti-inflammatory drugs with mast cells in the rat.”

The medical jury appears to be …confused… on salicylates. Some studies say they inhibit anaphylactic shock, others say they make anaphylactic shock worse.

On the subject of mast cells and salicylates, a blood relative of mine suffers from chronic urticaria, which is frequently treatable with failsafe.

Mastocytosis is due to the excess of normal-appearing mast cells in the skin. The three forms include urticaria pigmentosa, solitary mastocytomas, and diffuse cutaneous mastocytosis. The pediatric cutaneous form is the most common. […] Patients should be instructed to avoid medications that precipitate mast cell mediator release. These agents include: aspirin, NSAIDs, codeine, morphine, alcohol, thiamine, quinine, opiates, gallamine, decamethanonium, procaine, radiographic dyes, dextran, polymyxin B, scopalamine, and D-turbocurarine. Dietary substances that should be avoided are salicylates, crawfish, lobster, alcohol, spicy foods, hot beverages, and cheese. Journal of the American Osteopathic College of Dermatology [pdf]

This is a very interesting list of foods, because it implies that salicylates, many salicylate-like aromatics, amines, glutamates and opioids stimulate mast cell release. Histamine certainly does, but by the looks of it anyone with an inflammatory or immune condition should think twice about sticking any food chemicals in or on their body.

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Written by alienrobotgirl

7 April, 2006 at 8:54 am

Posted in The Science of FCI

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