Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis


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Manganese is found largely in whole grains, tree nuts, mollusks, some vegetables, and tea.

Several of the manganese deficiency symptoms are very interesting to me.

Manganese deficiency during growth:

  • Shorter, thicker bones
  • Small feet and shortened forearms (forearms and feet are always the same length as each other)

This is me. I never ate grains in any quantity as a child because they upset my stomach. Neither did I eat nuts, vegetables, or shellfish. I am small, with stubby arms and fingers. I have UK size 3 feet, which makes it very difficult to get high heels that fit, and means sometimes I have to buy children’s shoes. But I have a thickset frame. My bone structure is not at all delicate. This is to some extent inherited from my Dad. My sister is similar but not as thickset, with size 4 feet, and she ate bread when she was growing up.

Manganese is required in order to manufacture superoxide dismutase, an anti-inflammatory, immune calming substance. Interestingly, manganese deficiency can also cause cholesterol to be too low.

Some of manganese’s functions in the body can be taken over by magnesium, or by choline. Manganese is required for the synthesis of choline. In other words, it’s an essential part of the methylation cycle, since SAMe is used to manufacture acetylcholine. Manganese, magnesium, and choline, are all important in preventing epileptic seizures.

Manganese is an interesting mineral, because it needs to be kept in balance with zinc and copper. We hear “blah blah blah” from alternative medicine types about the zinc:copper ratio all the time, but actually it should be a zinc:copper:manganese ratio. Too much of any one can cause a deficiency in another. For example, too little manganese may cause an excess of copper.

Furthermore, calcium supplements can interfere with manganese absorption. I’ve never got on with calcium supplements, because they exacerbate the leg pain caused by my DVT. Interestingly, manganese helps to create anti-clotting factors in the blood. Furthermore, manganese deficiency can produce a selenium deficiency. Selenium along with A, C and E, is part of the body’s essential antioxidant machinery. Manganese deficiency can also produce pancreatic dysfunction, including elevated insulin. Manganese can also antagonise or be antagonised by iron. More.

However, monoamine and diamine oxidase are copper and iron containing enzymes, and therefore should be antagonised by excessive manganese. A good reason not to get carried away.


Written by alienrobotgirl

3 May, 2006 at 11:28 am

Posted in Vitamins

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