Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Nocturnal seizures revisited

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I wrote a brief article about coping strategies for nocturnal seizures not too long ago. There is a lot of contradictory information about the role of melatonin in seizures. I guess it serves me right for taking advice from an epilepsy charity website.

Some seizures are made less likely by melatonin. Other seizures are made more likely. The situation is confused. In some situations, melatonin appears to inhibit GABA. In others, it seems to enhance its action. Why? I am interested in finding out whether Juvenile Myoclonic Epilepsy (JME) is helped or hindered by melatonin production. If you have a seizure at night, is it automatically a “nocturnal seizure”? No, not necessarily. A nocturnal seizure would take place during sleep. JME is a condition where seizures are more likely just as you are falling asleep, but seizures are less likely during sleep. So might melatonin actually help? This is an interesting article about melatonin (free, but you have to register).

What we can say about JME is that it appears to be worsened by serotonin intoxication. Serotonin is a precursor for melatonin. Is it an antagonist? An agonist? Unrelated? Who knows?


Written by alienrobotgirl

7 May, 2006 at 3:16 pm

Posted in Neurotransmitters

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