Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Flat chested? Stop smoking!

with 2 comments

Many of the sex hormones are made up of different configurations of amino acids and aromatic rings. Aromatase is a cytochrome P450 enzyme (CYP19) that converts androgens (“male” sex hormones) into estrogens (“female” sex hormones).

Factors known to increase aromatase activity include age, obesity, insulin, gonadotropins, and alcohol. Aromatase activity is decreased by prolactin, AMH, and smoking. Aromatase activity appears to be enhanced in certain estrogen-dependent local tissue next to breast cancer, endometrial cancer, endometriosis, and uterine fibroids. Wikipedia

The next time you socialise with female friends or colleagues, look around and see if you can spot the difference between the smokers and non-smokers. I’ve just taken a long look around the office I work in, and on average, the female smokers may weigh less than the female non-smokers, but they also seem have the least feminine figures.

If lowering your insulin helps you to increase your testosterone levels, I wonder whether aromatase activity explains some of the physical effects of a low carbohydrate diet?


Written by alienrobotgirl

15 August, 2006 at 1:46 pm

2 Responses

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  1. I bet you don’t post this!!!!!!I have been reading through what ever I can find on the net about both Salicylates & Amines & have just read you article about flat “chested give up smoking” What a load of crap.!! I know smoking is bad for you & that at 48 Y.O. I should give up but if I do indeed have an intolerant to both Salicylates & Amines as well as fighting a financial battle on 3 fronts I personal find that stress is the main contributing element to my pain. I have 4 kids, 3 girls aged 26, 24, 21 & a boy 16 the eldest & youngest have both moved to Q/land with their boyfriends living in a de facto relationship & all are gainfully employed the middle daughter has gotten married & is building a house in Sydney’s north west. I myself am living in a separated marriage with my estrange wife, having had a car accident 7 years ago I need my son to help me around the house. My estranged wife was always a big woman WITH BIG BOOBS & she smoked right up to falling pregnant with our first child the took it up again when she stopped breast feeding, started again the stopped when we started to try for a 2nd child & hasn’t smoked since, she had 2 elder brothers & 2 elder sisters on was big & one was slender WITH BIG BOOBS & guess what she was the smoker !!!!. Now back to my children as of this moment in time non of them smoke the eldest did try when at school but didn’t take it up the 2nd on as far as I know has never tried & the 3rd has not had a smoke for about 8 month even after being a passenger in a serious car accident but she smoked from the time she hit high school. The 2 eldest girls always have trouble with their weight but guess what they are flat chested. We have always joked about them having to wait until they have kids to get tit’s. The 3rd child even now is like me & can eat what ever she wants & not put on to much weight but ask her boy friend why he started to chase her & he has no hesitation in saying it was her big tits. I haven’t done the research you seem to have done but I think if you look closer you will find that it has lot more to do with their heredity then weather they smoke. At least us smokes have & are now more then ever paying our own way with all the ever increasing taxes imposed on each & ever gram of tobacco & that’s more then can be said about the obesity problems the world is going through & the associated health problem they are causing !!!!! Leave the smokes alone!!!!!!!!!!!!!!Hoping to hear backPeter


    21 August, 2006 at 1:53 pm

  2. Actually as I believe people are inherently equal, I post all comments, regardless of how idiotic they are, or whether they’re posted by blog trolls who use inappropriate language like “tits” and “boobs” on a science-based blog site. I can only reply to such a pathetic response with arsenic-laced irony.1) I’ve never seen a clearer example of Oppositional Defiance Disorder. Talk about disproportionate, uncontrolled anger. Your thinking, writing, grammar, punctuation and spelling is disordered and includes many irrelevant details whilst missing out important facts. This makes you appear to be a crazy person. This is a textbook example of what food intolerance does. I am not surprised you suspect you have a problem.2) Salicylate and amine consumption causes “stress” and makes one less able to cope with difficult situations, so don’t assume that food intolerance is not playing a role in your ability to cope and that your reactions and emotions are all purely in response to situational factors without considering chemical factors too.3) Cigarettes are loaded with salicylates, so if you do have food intolerance problems (which seems most likely considering your bizarre rude and angry attitude), you will have to stop defending your beloved cigarettes and give them up, because they are part of your problem!4) I do not care whether smokers “pay their way” with taxes or not. I do not care whether obese people “pay their way” or not. I do not care about the financial consequences of ill health. I don’t indulge that kind of right-wing rhetoric on my site. I only care about the human consequences of ill health. Get your priorities straight!5) Your response is illogical and disproportionate because you are working on the false assumption that I am unaware of or I am denying that other biological factors other than aromatase activity are involved in breast size. Please credit me with some intelligence, and stop making yourself appear to be stupid by patronising me about heredity! The post was a light-hearted (obviously you didn’t get the humour that runs through this blog) look at how biology can be influenced by chemistry. There are many factors which influence breast-size. Whilst genetics do play a part, they largely play a part through hormonal levels. Hormonal levels are also influenced by the environment (such as chemical pseudoestrogens), circumstance (such as becoming pregnant), medication (such as the pill or other drugs which have a secondary influence on oestrogen levels), emotion (testosterone rises and falls in response to a variety of emotional responses), by the things we eat (such as the phytoestrogens found in soy, natural food chemicals like salicylates, and vitamin and mineral levels in the body), and also non-genetic congenital factors (such as the environment of the womb, which plays a part in “programming” hormonal levels through life). Suggesting that breast-size is mere genetics is utterly erroneous.6) How about instead of spewing out such nonsense, you write to tell me “Gee, thanks for all the hours and hours of hard work you have put in to publish all of this free information on the web for people like me who are suffering from possible food intolerance! I can’t thank you enough for helping me out, and I would not want to discourage you from writing by sending you random, meaningless abuse!”

    Alien Robot Girl

    21 August, 2006 at 5:08 pm

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