Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Salicylates, bacteria, and skin conditions

with 4 comments

Salicylates increase the resistance of bacteria to antibiotics: pseudomonas cepacia, staphylococcus aureus.

Mmm. Pseudomonas and staph, really nice bacteria. Those can both become very bad dermatological infections.

Staph has been linked closely with eczema and atopic dermatitis. “These findings indicate that atopic dermatitis patients have an impaired immune response that prevent them from producing adequate amounts of antimicrobial peptides in their skin. […] Two immune hormones secreted by their skin cells, IL-4 and IL-13 suppressed the production of at least one of the peptides.”

Salicylates inibit or affect the production of the aforementioned IL-13 and IL-4 (interleukin-13 and interleukin-4) in human beings, the mechanisms by which our skin is protected from these infections.

Yet salicylates ARE a kind of antimicrobial in plants, and have apparently been shown to reduce virulence of staph.

Salicylates disorganise the immune system. Salicylates increase the resistance of staph to antibiotics. Salicylates are linked to eczema and dermatitis. Staph is linked to eczema and dermatitis. Yet, salicylates are supposed to kill staph?

I’m confused.

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Written by alienrobotgirl

29 September, 2006 at 2:52 pm

Posted in The Science of FCI

4 Responses

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  1. I can understand your confusion. Hopefully I might have some ideas that can reduce it. Bear in mind, the ideas I present are ideas, not verified theories. They are however in line with holistic medicine.Assume for a moment a wonderful world in which humans that eat what they were designed to eat never get sick. In this world there are of course bacteria and viruses, yet they to a large extent do not make humans sick (enough to affect their survival). How is this possible? My idea is that humans have evolved to deal with the common viruses and bacteria in the environment using the following strategy: each and every cell in a healthy human produces appropriate antiviral and antimicrobial substances. One of the traits of a healthy human being is that the genes that code for these substances are expressed. I am trying to understand holistic medicine/healing more scientifically. One morning, as I woke up, I had an idea. What if “toxins” (as termed by practioners of some holistic medicine) accumulating in cells affect the genetic expression in these cells by binding to the “outside” of the DNA and thus blocking some genes from being expressed? “Toxin” molecules bind to specific sites on the DNA and inhibit expression of proteins coded for at these sites. Assume that cells without “toxins”, and thus with normal gene expression, are in perfect balance and contain antimicrobial and antiviral proteins. Some “toxins” will inhibit expression of these proteins and thus the cell will become “infected”. The cause of the infection is not (…well it depends on how you look at it) the microbe or virus, but the “toxin” (or substance that should not be present) in the cells that inhibited genetic expression of antimicrobial/antiviral proteins naturally present in “healthy” cells. Many “s, due to most of these thoughts being ideas at at early stage.Now to your example that gave me a beginning of an aha. What if salicylates inhibit expression of IL-3 and IL-4, and by the binding of salicylates to the “outside” of the DNA they are locked up and do not function as an antimicrobial substance? -Raw Paleo John

    Anonymous

    2 October, 2006 at 6:23 pm

  2. The below is a quote from an email that someone with suspected food chemical intolerance sent me in response to this post:”You wrote: ‘Staph has been linked closely with eczema and atopic dermatitis. “These findings indicate that atopic dermatitis patients have an impaired immune response that prevent them from producing adequate amounts of antimicrobial peptides in their skin. […] Two immune hormones secreted by their skin cells, IL-4 and IL-13 suppressed the production of at least one of the peptides.”‘”You may find it interesting that in April, upon visiting a local dermatologist, a swab was taken of an open eczematous area on my right hand, and from that swab a staph. aureus bacterium culture was confirmed as residing at the site of the sample.”

    Alien Robot Girl

    3 October, 2006 at 2:12 pm

  3. I have not yet started my blog, but will post this for your information.The homocysteine theory of heart disease shows the importance of B6, folic acid, B12, flavonoids etc in preventing heart disease.http://www.amazon.co.uk/Heart-Revolution-Kilmer-S-McCully/dp/0060929731/sr=8-1/qid=1160045644/ref=sr_1_1/026-8602276-6161240?ie=UTF8&s=booksOne of the comments is interesting:”just did a quick read mar 99, and there is one very important nutrient that is not even mentioned that is more powerful than any of the b vitamins mentioned(folate, b12,b6) for lowering blood homocysteine levels. it is called TMG, or trimethylglycine, derived from sugar beets, which is CHEAP, and available at only a few health food stores. don’t bother to ask your doctor about it; they are in the stone age WRT knowledge about nutrition, and they haven’t even heard of homocysteine yet! there is a huge database of clinical support that shows just how powerful TMG is. TMG is a methyl-group donor, which degrades to DMG when it has donated one methyl group to homocysteine to render it harmless. it acts in DAYS to bring down the blood homocysteine level. dr. mccully deserves the nobel prize in medicine for his research and discovery, yet the establishment that ignored and ostracized him for so long will no doubt see to it that he either never receives it, or, like peyton rous, who received the nobel prize in 1966 for the cancer-causing virus he discovered in 1911(!),gets it very, very late.”Now to backtrack a bit. I am going to quit coffee in order to get rid of the pimples, that have become more after now three weeks of coffee drinking. I am therefore looking for foods to eat to detoxify the skin. Home-made liver pate is the solution (why will be obvious shortly). I searched for riboflavin, salicylate and detoxification in google and came across:http://www.thorne.com/pdf/journal/3-3/detoxificationenzymes.pdf#search=%22salicylate%20riboflavin%20detoxification%20pathway%22On page 189 I read about the Liver detoxification pathways I looked at the enzymes and cofactors involved in phase I detoxification. With the exception of flavonoids it looks like the nutrient content of liver, with b-vitamins and phospholipids. Therefore I should eat liver and egg yolks to detoxify. Liver pate some days and beef tartar almost all days is an excellent diet.Now to my reason for this post: The connection between detoxification and the homocysteine theory of heart disease. I cannot avoid seeing heart disease as an inflammation/infection/toxification. I may be seeing to many connections here…What happens when cells other than skin cells are overloaded with toxins such as salicylates? What if these are cells lining the arteries? Are the local antimicrobial compounds inhibited, resulting in an infection?-Raw Paleo John

    Anonymous

    5 October, 2006 at 11:20 am

  4. Hi Raw Paleo John,The heart disease connection is an interesting point, because there is a theory that heart disease is an autoimmune condition, and several autoimmune conditions have been helped by the failsafe. Salicylates inhibit the production of essential sugars and glycoproteins that prevent food lectins from attaching to cell surfaces and causing immune dysfunction.I’ve written a few things about methylation, TMG and liver detox pathways in the past that I should really revise and post again.This looks like a great PDF you came across! I will have to sit down and read it properly.I would urge caution when eating liver, however, as it degrades very, very quickly so is liable to contain amines.

    Alien Robot Girl

    16 October, 2006 at 9:35 am


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