Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Fallon leukemia cluster and sulphite oxidase gene

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11 of 15 leukemia patients have genetic variation, researchers say.

CARSON CITY — Federal researchers have found that children who are part of a Northern Nevada cancer cluster have a variation in a gene that helps combat unsafe chemicals.

Eleven of the 15 children diagnosed in the Fallon leukemia cluster between 1997 and 2001 submitted to DNA testing, and the variation in the gene was found in all 11 children tested. The gene, called SUOX, tells the body how to make sulfite oxidase, an enzyme that changes an unsafe chemical into a safer one.

The study released by the Centers for Disease Control and Prevention is the latest to suggest genetics and toxins play a role in the cancer cluster plaguing the rural agricultural community.

But Dr. Carol Rubin, chief of the CDC’s health studies branch, said the variation in the gene was also found in 40 percent of Fallon children in a comparison, or healthy group.

“The variations may mean something, and they may not mean something,” she said. “The fact that all the case children had the variation, and 40 percent of the comparison children did too, is a striking finding. FALLON CANCER CLUSTER: Gene link found in children

I keep finding links between poor liver detoxification and cancer.

The genetics, heavy metals and drinking water areas of study are related to previous research that indicates some of the Fallon children who got leukemia had the same variation in a gene that helps the body detoxify and are related to air and water tests showing high concentrations of the metals tungsten and cobalt in Fallon’s environment.

Witten and his partner, Paul Sheppard, at the University of Arizona have found high levels of tungsten in tree rings and air samples in Fallon. Sheppard, in a recent peer-reviewed research paper, found high concentrations of the metal in lichens on rocks in the Fallon area.

Tungsten has not been shown to cause leukemia, but research by Witten and others indicates that tungsten in combination with other metals, including cobalt, can damage DNA in cells. Fallon leukemia cluster research to continue

Previously the US government had managed to find “no link” between the suspiciously high tungsten and other mentals in the Fallon environment and the leukemia cluster.

A federal study of a childhood leukemia cluster in this farming and military town found high amounts of tungsten and arsenic in most residents but nothing to indicate that either caused the cancer. Federal study finds no environmental link to Fallon leukemia cluster

According to this article there are several old tungsten mines in the area and a tungesten carbide factory in town.

It is not surprising that there is a link between tungsten, a genetic sulphite oxidase enzyme variation, and leukemia. It has been previously noted several times that tungsten displaces molybdenum, the crucial cofactor for the production of sulphite oxidase – making already vulnerable children with a genetic variation even more vulnerable.

Molybdenum deficiency has already been associated with other types of cancer. Sulphites are another example of an antioxidant that can cause cancer.

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Written by alienrobotgirl

10 December, 2006 at 6:49 pm

Posted in The Genetics of FCI?

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