Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Relaxin, fertility, fibromyalgia

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One of the riddles of fibromyalgia and myofascial pain is relaxin, a hormone we typically associate with pregnancy. Relaxin makes your muscles and collagen relax. A deficiency in relaxin makes you tense and makes your muscles stiffen up. Relaxin may be the reason that some fibromyalgia sufferers get better temporarily when they are pregnant.

Says a fibromyalgia self help site:

Dr. Sam Yue (www.samyue.com) surmises that fibromyalgia and CMP are caused by a deficiency in the hormone “relaxin.” Relaxin is the hormone that, in pregnant women, relaxes the cervix and pelvis in preparation for birth. However, relaxin receptors can be found in all the connective tissues. A relaxin deficiency could disrupt connective tissue function. Dr. Yue thinks relaxin deficiency might play a part in creating porous intestinal tissue, thereby resulting in leaky gut syndrome (see below), another possible cause of fibromyalgia. Possible Causes and Perpetuators of FMS and CMP

Says a study in pubmed:

The stimulatory effect of AA [arachidonic acid] (10 microM) on relaxin release was almost wholly blocked by a cyclooxygenase inhibitor (ibuprofen; 20 microM). Analysis of relaxin release by cultured porcine luteal cells using a reverse hemolytic plaque assay: effects of arachidonic acid, cyclo- and lipooxygenase blockers, phospholipase A2, and melittin.

Not only this but: Relaxin Induces Cyclooxygenase-2 Expression in Cultured Normal Human Endometrial Stromal Cells. “The targeted disruption of COX-2, but not COX-1, in mice results in defective reproductive processes, including implantation failure.”

Salicylates are COX2 inhibitors. Is it any wonder in a world deficient in arachidonic acid and burdened down with junk food, synthetic hormones, pseudo-oestrogens and rampant pain killer popping, that we are becoming infertile?

Relaxin also activates the L-arginine nitric oxide biosynthesis pathway, which makes one wonder about relaxin deficiency having a role in heart disease and hypertension. Could natural variation in relaxin levels influence fibromyalgia or food chemical intolerance?

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Written by alienrobotgirl

14 December, 2006 at 12:35 pm

Posted in The Science of FCI

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