Factor V Leiden and vitamin E
After I had my Factor V Leiden related DVT, I used vitamin E to thin my blood for a year or so, especially if I knew I was going to fly on a plane. I found 400iu to be an effective dose – effective in that if I cut myself I would bleed for longer than normal, and I bruised more easily. People who clot easily often do not bruise – I hardly bruised for most of my youth (problematic if you are being bullied). Alpha tocopherol was more effective than mixed tocopherols/tocotrienols.
A report published online on September 10, 2007 in Circulation: Journal of the American Heart Association concluded that supplementing with vitamin E may reduce the risk of venous thromboembolism (VTE) among women. The condition occurs when blood clots form in the veins, which subsequently dislodge and travel through the bloodstream, and is life-threatening when the clots block circulation to the brain, heart or lungs. The current treatment is warfarin, a blood thinner which often has side effects.
In the current study, which was funded by the National Institutes of Health, Robert J. Glynn, PhD, ScD and his Harvard colleagues reviewed data from The Women’s Health Study, a randomized trial of 39,876 women who received 600 international units vitamin E every other day or a placebo for a ten year average period. Over the course of the study, 213 women who received vitamin E and 269 in the placebo group developed venous thromboembolism, indicating a 21 percent risk reduction associated with the vitamin compared with the placebo. For unprovoked venous thromboembolism, which is not caused by trauma, surgery, or cancer, vitamin E supplementation was associated with a 27 percent reduction in risk.
In a subgroup of 1,131 women who reported a history of venous thromboembolism prior to the trial, the condition was reduced by 44 percent in the vitamin E group, while among those with no history, the risk was 18 percent lower. And, among women found to have one of two genetic mutations associated with increased VTE risk (factor V Leiden and the G20210A prothrombin mutation), vitamin E supplementation was associated with a 49 percent reduction in the risk of occurrence compared with women in this category who received the placebo.
“Women who had an event before the study had a much higher event rate during the study, and the vitamin E worked a little better in that population than in the general population, when it came to reducing VTE risk,” noted Dr Glynn, who is an associate professor of medicine at Harvard Medical School. “It seems that women who would particularly be interested in a preventive agent actually seemed to have a larger benefit.”
“While warfarin is quite effective for preventing VTE, we were looking for a preventive strategy that might be simple, with low side effects for this common disease,” he stated. “In this study, VTE occurred more often than heart attacks and almost as often as stroke. People don’t realize how common it is.” LEF: Vitamin E supplementation helps prevent venous thromboembolism
Vitamin E also seems to inhibit leukotriene production, and I often wonder whether this is one of the many reasons I suffered from less rashes, hives, and itching during that time.