Autoimmune Thyroid Disease

An Unfortunate and Lengthy Adventure in Misdiagnosis

Adenoviruses, hypothyroidism, and obesity

with 3 comments

Subacute thyroiditis is presumed to be caused by a viral infection or a postviral inflammatory process. The majority of patients have a history of an upper respiratory infection prior to the onset of thyroiditis (typically two to eight weeks beforehand). The disease has been thought to have a seasonal incidence (higher in summer) [2], and clusters of cases have been reported in association with Coxsackievirus, mumps, measles, adenovirus, and other viral infections [1]. Serial studies of viral antibody titers have implicated many of the same viruses, but the changes could equally be attributed to nonspecific anamnestic responses [3]. Viral inclusion bodies are not seen in thyroid tissue. Furthermore, there appears to be a relatively comparable distribution of presentation throughout the year [4,5]. Thyroid autoimmunity does not appear to play a primary role in the disorder, but it is strongly associated with HLA-B35 in many ethnic groups [6]. A unifying hypothesis might be that the disorder results from an often subclinical viral infection that provides an antigen, either of viral origin or resulting from virus-induced host tissue damage, that uniquely binds to HLA-B35 molecules on macrophages. The resulting antigen-HLA-B35 complex activates cytotoxic T lymphocytes that then damage thyroid follicular cells, because the cells have some structural similarity with the infection-related antigen. Unlike autoimmune thyroid disease, however, the immune reaction is not self-perpetuating, so the process is limited. Subacute granulomatous thyroiditis

Whatever form of subacute thyroiditis I had, I’m very interested in adenoviruses. Says Wikipedia, “Recently, several adenoviruses, especially adenovirus 36 (AD-36), have been shown to cause obesity in animals, and are associated with human obesity.”

I’ve argued on previous occasions, based on my own experience of my elastic metabolism, that a calorie is not always a calorie. I have posted on AD-36, the fat virus, and infectious obesity, a couple of times before. Some of the theories I have previously thrown into the field about what is wrong with me suddenly appear – gasp – actually likely to be true.

So not only do adenoviruses cause infections that can damage your thyroid, they appear to affect the metabolism in other ways too. I wonder if they cause some kind of mitochondrial dysfunction, as is speculated to occur in fibromyalgia?

I just thank my lucky stars I wasn’t infected with Coxsackie, which can cause polio.

Advertisements

Written by alienrobotgirl

13 June, 2009 at 7:46 am

Posted in Thyroid

3 Responses

Subscribe to comments with RSS.

  1. Is pertussis an adenovirus?? I got that shortly after I was born (about 3 months old, I think?) and nearly died of it.

    Annabelle

    sideshowbelle

    15 June, 2009 at 8:51 pm

  2. Pertussis is pertussis, but researchers have used it to induce autoimmune thyroiditis in rats. Wow, Belle.

    alienrobotgirl

    16 June, 2009 at 8:09 am

  3. Oh fantastic! :S Doomed from birth!

    sideshowbelle

    16 June, 2009 at 1:26 pm


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: